[Clinical studies of gamma-seminoprotein in prostatic disease. II. Immunohistochemical study of gamma-seminoprotein].

Abstract

Localization of gamma-seminoprotein (gamma-Sm) was examined using horseradish peroxidase-labeled anti-gamma-Sm antibody (Chugai Corp. Ltd., Tokyo, Japan) by the enzyme-labeled antibody method in paraffin embedded specimens of 18 benign prostatic hyperplasias and 32 untreated prostatic cancers. The level of serum gamma-Sm was also determined by enzyme immunoassay in 10 untreated patients with prostatic cancer and 18 with benign prostatic hyperplasia. Specific gamma-Sm staining was detected in prostatic glandular epithelial cells and prostatic secretion of all specimens of benign prostatic hyperplasias and a half of the specimens of prostatic cancers. Specific gamma-Sm staining was shown to correlate with histological differentiation of the prostatic cancer, but no correlation was found between specific gamma-Sm staining and the level of serum gamma-Sm.

• Authors: J Nakashima, S Hasegawa, Y Nakashima, S Nakamura, S Kimura, M Tachibana, N Deguchi, H Tazaki
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 33 Issue 12 Pg. 2059-63 (Dec 1987) ISSN: 0018-1994 [Print] Japan
• PMID: 3329454 (Publication Type: English Abstract, Journal Article)

Chemical References

• Prostatic Secretory Proteins
• Proteins
• Seminal Plasma Proteins
• beta-microseminoprotein

Topics

• Adenocarcinoma (analysis, diagnosis, pathology)
• Aged
• Humans
• Immunoenzyme Techniques
• Male
• Neoplasm Staging
• Prostatic Neoplasms (analysis, diagnosis, pathology)
• Prostatic Secretory Proteins
• Proteins (analysis)
• Seminal Plasma Proteins