Abstract | PURPOSE: METHODS: RESULTS: PDRN treatment relieved mechanical allodynia and alleviated thermal hyperalgesia after Achilles tendon injury. TNF-α and IL-6 concentrations were decreased by PDRN application. PDRN injection significantly enhanced cAMP concentration and phosphorylated CREB versus CREB ratio, showing cAMP-PKA-CREB pathway was activated by PDRN application. PDRN treatment inhibited percentages of cleaved caspase-3-positive cells and caspase-9-posiive cells and the suppressed Bax versus Bcl-2 ratio in Achilles tendon injury rats. CONCLUSION: PDRN is probably believed to have a good effect on pain and inflammation in the urogenital organs. PDRN may be used as a new treatment for Achilles tendon injury.
|
Authors | Jeong Ho Rho, Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Jun-Young Chung, Tae-Jun Hwang, Jin Hee Han |
Journal | International neurourology journal
(Int Neurourol J)
Vol. 24
Issue Suppl 2
Pg. 79-87
(Nov 2020)
ISSN: 2093-4777 [Print] Korea (South) |
PMID | 33271004
(Publication Type: Journal Article)
|