Abstract | BACKGROUND: MATERIAL AND METHODS: The researches implemented a triple-blind, randomized clinical trial. The study was conducted with ASA I individuals aging between 18 and 35 years, which were randomized and submitted to two interventions, one with 8mg dexamethasone and the other with 20mg ketorolac tromethamine given 1h before the procedure. The primary predictor variable was the use of dexamethasone or ketorolac. The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale. The secondary outcome variables were the amount of rescue analgesic consumed, swelling and trismus. Repeated-measures ANOVA and t-test for paired samples were used to compare the means. Significance was set at p < 0.05. RESULTS: Fifty individuals were randomized and allocated to intervention, and the sample was composed of 40 subjects who completed the study (27 female and 13 male). Dexamethasone, when compared to ketorolac tromethamine, showed a significantly higher reduction in pain level at 8h, 16h, 24h, 32h, 40h and 72h, in swelling and trismus at 24h, 48h, 72h and 7 days and in total number of rescue analgesics taken up to 72h postoperative (p < 0.05). CONCLUSIONS:
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Authors | A-V Martins-de-Barros, A-M Barros, A-K Siqueira, E-E Lucena, P-H Sette de Souza, F-A Araújo |
Journal | Medicina oral, patologia oral y cirugia bucal
(Med Oral Patol Oral Cir Bucal)
Vol. 26
Issue 2
Pg. e141-e150
(Mar 01 2021)
ISSN: 1698-6946 [Electronic] Spain |
PMID | 33247572
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Dexamethasone
(therapeutic use)
- Double-Blind Method
- Edema
(etiology, prevention & control)
- Female
- Humans
- Ketorolac
- Male
- Molar, Third
(surgery)
- Pain, Postoperative
(prevention & control)
- Tooth Extraction
(adverse effects)
- Tooth, Impacted
(surgery)
- Trismus
(etiology, prevention & control)
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