[Lithogenicity and bile acid pattern in choleretic administration (3-n-butoxy-1-phenoxy-propanol: febuprol) in patients with functional right upper quadrant pain].

Abstract

10 patients with right upper quadrant pain were treated with a choleretic agent (Febuprol; 3 X 200 mg t. i. d.) and placebo in a cross-over double dummy technique for 16 weeks. Lithogenic index, bile acid profile and serum lipids were determined every 4 weeks. During Febuprol application the clinical symptoms were relieved (0.87 +/- 1.3 vs. 1.39 +/- 0.21 (placebo); p less than 0.05, semiquantitative score). Biliary lithogenicity (1.45 +/- 0.6 vs. 1.09 +/- 0.12; n. s.), bile acid profile and serum lipids showed no statistically significant change, although serum cholesterol levels seemed to fall during Febuprol application.

• Authors: W Swobodnik, J G Wechsler, U Klüppelberg, P Janowitz, V Hutt, H Ditschuneit
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 25 Issue 11 Pg. 715-20 (Nov 1987) ISSN: 0044-2771 [Print] Germany
• Vernacular Title: Lithogeniät und Gallensäurenmuster unter Choleretikagabe (3-n-Butoxy-1-phenoxy-propanol: Febuprol) bei Patienten mit funktionellen rechtsseitigen Oberbauchbeschwerden.
• PMID: 3324520 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Bile Acids and Salts
• Cholagogues and Choleretics
• Lipids
• Phenyl Ethers
• Propanols
• 1-Propanol
• febuprol

Topics

• 1-Propanol (therapeutic use)
• Adult
• Bile Acids and Salts (blood)
• Cholagogues and Choleretics
• Cholelithiasis (blood, drug therapy)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Humans
• Lipids (blood)
• Male
• Middle Aged
• Phenyl Ethers
• Propanols