The efficacy of different insulin-sensitizing agents on treatment outcomes in patients with polycystic ovary syndrome who underwent in-vitro fertilization: A retrospective, record-based, comparative study.

Abstract

INTRODUCTION:

It is not clear which metformin or inositol is more effective on IVF results. The aim of this study was to compare the effects of Metformin and Inositol co-treatments on IVF outcomes in Polycystic ovary syndrome patients.

METHODS:

A retrospective examination was made of the demographic characteristics and the follicular-embryonic development results of PCOS patients applied with an antagonist protocol of ovarian hyperstimulation in the first cycle of IVF with co-treatment of Metformin at 2000 mg/day regularly for 3 months (Metformin co-treatment group, n:35) or Inositol at 4000 mg/day myo-inositol for 3 months (Inositol co-treatment group, n:34) and those not using any co-treatment (FSH only group [control group], n:40).

RESULTS:

No significant difference was determined between the groups in respect of demographic characteristics. The HOMA-IR scores and hCG day E2 level were significantly higher in the control group than in both co-treatment groups (p = 0.021, p = 0.018, respectively). The M1 oocyte count was significantly lower in the Metformin group than in the Inositol and control groups (p = 0.001). The GVDJ oocyte count was significantly lower in both co-treatment groups than in the control group (p = 0.042). No statistically significant difference was determined between the groups in respect of other follicular and embryological development parameters, implantation, clinical pregnancy, live births and abortus rates.

CONCLUSION:

Insulin-sensitizing agents may have positive effects on follicular development in PCOS patients applied with IVF.

• Authors: Aslı Yaylalı, Murat Bakacak, Zeyneb Bakacak
• Journal: Journal of gynecology obstetrics and human reproduction (J Gynecol Obstet Hum Reprod) Vol. 50 Issue 1 Pg. 102006 (Jan 2021) ISSN: 2468-7847 [Electronic] France
• PMID: 33242676 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Chemical References

• Chorionic Gonadotropin
• Hypoglycemic Agents
• Vitamin B Complex
• Inositol
• Metformin

Topics

• Adult
• Case-Control Studies
• Cell Count
• Chorionic Gonadotropin (blood)
• Female
• Fertilization in Vitro
• Humans
• Hypoglycemic Agents (therapeutic use)
• Inositol (therapeutic use)
• Metformin (therapeutic use)
• Oocytes
• Polycystic Ovary Syndrome (drug therapy)
• Retrospective Studies
• Vitamin B Complex (therapeutic use)
• Young Adult