Management guideline for Werner syndrome 2020. 3. Diabetes associated with Werner syndrome.

Abstract

AIMS:

To evaluate the characteristics of diabetes associated with Werner syndrome.

METHODS:

A literature search was done with search term "Werner syndrome" and "Diabetes".

RESULTS AND CONCLUSIONS:

Prevalence of diabetes is extremely high in Werner syndrome. Diabetes associated with Werner syndrome is classified as "accompanied with other diseases and conditions and the one occurring mainly in association with other genetic syndromes." This type of diabetes is marked by accumulated visceral fat and high insulin resistance, despite low body mass index. Thiazolidine derivatives and metformin are effective for glycemic control. New antidiabetic drugs, such as dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists, could be potentially beneficial for patients with Werner syndrome. Furthermore, the establishment of diet therapy as well as exercise therapy is warranted. Geriatr Gerontol Int 2021; 21: 142-145.

• Authors: Minoru Takemoto, Yoshitaka Kubota, Toshibumi Taniguchi, Sei-Ichiro Motegi, Akira Taniguchi, Hironori Nakagami, Yoshiro Maezawa, Masaya Koshizaka, Hisaya Kato, Kazuhisa Tsukamoto, Seijiro Mori, Masafumi Kuzuya, Koutaro Yokote
• Journal: Geriatrics & gerontology international (Geriatr Gerontol Int) Vol. 21 Issue 2 Pg. 142-145 (Feb 2021) ISSN: 1447-0594 [Electronic] Japan
• PMID: 33169495 (Publication Type: Journal Article)
• Copyright: © 2020 Japan Geriatrics Society.

Chemical References

• Dipeptidyl-Peptidase IV Inhibitors
• Hypoglycemic Agents
• Metformin

Topics

• Diabetes Mellitus, Type 2
• Dipeptidyl-Peptidase IV Inhibitors
• Humans
• Hypoglycemic Agents (therapeutic use)
• Metformin (therapeutic use)
• Werner Syndrome