Antimullerian Hormone as a Serum Biomarker for Risk of Chemotherapy-Induced Amenorrhea.

Abstract

Antimullerian hormone (AMH) is a promising biomarker for ovarian reserve. In this study, we assessed AMH before and 1 year after initiation of adjuvant chemotherapy on National Surgical Adjuvant Breast and Bowel Project (NSABP)/NRG Oncology B-47 in female participants aged 42 years and younger (median age = 39 years). At baseline, median AMH was 1.2 ng/mL; 13 (4.7%) values were less than 0.1 ng/mL (the threshold for detectable levels, in the perimenopause and menopause range), and 57 values (20.6%) were less than 0.5 ng/mL. At 1 year, 215 (77.6%) were less than 0.1 ng/mL, and 264 (95.3%) were less than 0.5 ng/mL. Postchemotherapy menses were reported by 46.2% of participants. Multivariable logistic regression found that the odds of having postchemotherapy menses increased with younger age, higher body mass index, and higher prechemotherapy AMH, but not by trastuzumab administration or by the choice of chemotherapy (doxorubicin-cyclophosphamide followed by paclitaxel vs docetaxel-cyclophosphamide). We conclude that higher prechemotherapy AMH predicts a lower risk of chemotherapy-induced amenorrhea and that AMH 1 year after chemotherapy initiation is not informative in this setting because it is likely to be very low.

• Authors: Kathryn J Ruddy, Daniel J Schaid, Anthony Batzler, Reena S Cecchini, Ann H Partridge, Aaron Norman, Louis Fehrenbacher, Elizabeth A Stewart, Emanuel Trabuco, Elizabeth Ginsburg, Fergus J Couch, Peter A Fasching, Celine Vachon, Patricia A Ganz
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 113 Issue 8 Pg. 1105-1108 (08 02 2021) ISSN: 1460-2105 [Electronic] United States
• PMID: 33159444 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please email: [email protected].

Chemical References

• Antineoplastic Agents
• Biomarkers
• Anti-Mullerian Hormone

Topics

• Adult
• Amenorrhea (chemically induced)
• Anti-Mullerian Hormone (adverse effects)
• Antineoplastic Agents (adverse effects)
• Biomarkers
• Breast Neoplasms (drug therapy)
• Chemotherapy, Adjuvant (adverse effects)
• Female
• Humans