Asthma is an allergic chronic inflammatory disease of the pulmonary airways, characterized by the infiltration of white blood cells and release of inflammatory
cytokines of complex pathways linked to its pathogenesis.
Syringin extracted from various medicinal plants has been used extensively for the treatment of inflammatory diseases. Hence, this study was conducted to further explore the protective effects of the
syringin in
ovalbumin (OVA) induced-
asthma mice model. OVA-sensitized BALB mice were treated intraperitonealy with three doses (25, 50 and 100 mg/kg) of the
syringin which was validated by the alteration in the
immunoglobulin E (
IgE) levels,
cytokines levels, histopathological evaluation inflammatory cell count, lung weight,
nitrite (NO) levels, oxidative stress
biomarkers and gene markers. The treatment of
syringin intensely reduced the increased
IgE, inflammatory
cytokines, WBC count and restored the
antioxidant stress markers OVA stimulated animals. In addition, a significant reduction in
inflammation and mucus production was evidenced in histopathological analysis which was further validated by suppression NF-κB pathway activation by
syringin. These results suggest that
syringin may improve
asthma symptoms in OVA-induced mice by modulating NF-κB pathway activation.