Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: KEY RESULTS: Comparing the potency of Δ9 - THC to inhibit DOI-induced repetitive behaviours, the rank order was ESR > grooming > HTR versus ESR = grooming > HTR in young adult versus juvenile mice. Δ9 - THC (5 mg·kg-1 ) induced severe adverse effects in the form of cataleptic behaviour in control mice and significantly increased ESR in juveniles. The pharmacological effects of CBD have not been studied in models of Tourette syndrome. In juveniles, CBD had no effect on DOI-induced ESR and grooming behaviours. CBD alone induced side effects, significantly increasing the frequency of HTR in juveniles and young adults. CONCLUSION AND IMPLICATIONS: Δ9 - THC efficaciously reverses peripheral but not central motor tics. Δ9 - THC may reduce ambulatory movements and evoke premonitory urges in some paediatric patients. The small "therapeutic window" in juveniles suggests that CBD may not effectively treat motor tics in children and may even exacerbate tics in a population of patients with Tourette syndrome.
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Authors | Victoria Gorberg, Peter McCaffery, Sharon Anavi-Goffer |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 178
Issue 3
Pg. 614-625
(02 2021)
ISSN: 1476-5381 [Electronic] England |
PMID | 33125731
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 The British Pharmacological Society. |
Chemical References |
- Medical Marijuana
- Cannabidiol
- Dronabinol
|
Topics |
- Animals
- Cannabidiol
(pharmacology)
- Child
- Decision Making
- Dronabinol
(pharmacology)
- Humans
- Medical Marijuana
- Mice
- Tourette Syndrome
(drug therapy)
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