Trichloroacetic acid 35% as a therapeutic line for localized patchy alopecia areata in comparison with intralesional steroids: Clinical and trichoscopic evaluation.

Abstract

BACKGROUND:

Intralesional corticosteroids (ILCs) is the first-line therapy for patients older than 10 years having patchy alopecia areata, however some patients do not respond effectively.

AIMS:

To evaluate the efficacy of a chemical peel trichloro acetic acid (TCA 35%) in comparison to ILCs.

PATIENTS/METHODS:

Twenty-two patients with two patches of alopecia areata were included. Two treatment modalities with ILCs and topical TCA 35% were performed in two randomly selected patches. Three sessions were done, 3 weeks apart and were followed-up for three months. Evaluation was done using Mac Donald Hull and Norris grading system and by counting trichoscopic parameters in each patch.

RESULTS:

Both ILCs and TCA 35% treated patches showed measurable improvement with no statistically significant difference between the results of the two modalities (p>0.05) at different times of the study. Yellow dots, black dots, exclamation marks and dystrophic hair were all reduced by 100%, 82.0%, 100% and 88.3% in ILCs treated patches and by 70.4%, 69.1%, 100% and 75.0% in TCA treated patches, respectively.

CONCLUSION:

Topical TCA 35% is an effective and safe treatment for the treatment of AA without serious side effects, despite the slower response when compared to ILCs.

• Authors: Doaa A Mahgoub, Tamarah I Dhannoon, Marwa S El-Mesidy
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 20 Issue 6 Pg. 1743-1749 (Jun 2021) ISSN: 1473-2165 [Electronic] England
• PMID: 33001537 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2020 Wiley Periodicals LLC.

Chemical References

• Steroids
• Trichloroacetic Acid
• Triamcinolone Acetonide

Topics

• Alopecia Areata (drug therapy)
• Humans
• Steroids
• Treatment Outcome
• Triamcinolone Acetonide
• Trichloroacetic Acid