Abstract | BACKGROUND: METHODS: We used a systematic pharmacological method to confirm whether the activation of the NLRP3 inflammasome in the hippocampus was involved in the development of neuropathic pain associated with mood disorders and whether albiflorin could be an effective treatment for these symptoms. RESULTS: The NLRP3 inflammasome contributed to the neuropathic pain and comorbid anxiety and depression-like behaviors induced by chronic constriction injury of the sciatic nerve, and albiflorin may relieve these symptoms via inhibition of the NLRP3 inflammasome activity. Moreover, albiflorin enhanced the translocation of the nuclear factor erythroid 2-related factor 2 into the nucleus and suppressed nuclear factor-kappa B activity in the hippocampus. CONCLUSIONS:
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Authors | Pei Liu, Jianjun Chen, Shuai Ma, Jianjun Zhang, Jianyu Zhou |
Journal | The international journal of neuropsychopharmacology
(Int J Neuropsychopharmacol)
Vol. 24
Issue 1
Pg. 64-76
(01 20 2021)
ISSN: 1469-5111 [Electronic] England |
PMID | 33000169
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2020. Published by Oxford University Press on behalf of CINP. |
Chemical References |
- Bridged-Ring Compounds
- Inflammasomes
- NLR Family, Pyrin Domain-Containing 3 Protein
- Nlrp3 protein, rat
- albiflorin
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Topics |
- Animals
- Anxiety
(drug therapy)
- Behavior, Animal
(drug effects)
- Bridged-Ring Compounds
(pharmacology)
- Constriction
- Depression
(drug therapy)
- Disease Models, Animal
- Hippocampus
(drug effects)
- Inflammasomes
(drug effects)
- Male
- NLR Family, Pyrin Domain-Containing 3 Protein
(drug effects)
- Neuralgia
(drug therapy, etiology)
- Peripheral Nerve Injuries
(complications)
- Rats
- Rats, Sprague-Dawley
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