Macular edema secondary to retinal vein occlusion in a real-life setting: a multicenter, nationwide, 3-year follow-up study.

Abstract

PURPOSE:

To evaluate the presence of macular edema secondary to retinal vein occlusion (RVO)-both central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO)-3 years after diagnosis in patients who underwent intravitreal therapy and to identify potential prognostic factors and biomarkers of persistent macular edema.

METHODS:

National multicenter, observational, exploratory, retrospective cohort study of 104 consecutive patients with macular edema secondary to RVO diagnosed from January 2014 to December 2015 with minimum 3-year follow-up time. Data analyzed included best-corrected visual acuity (BCVA), clinical and demographic data, and spectral domain optical coherence tomography parameters.

RESULTS:

At final observation, median baseline central retinal thickness significantly improved from baseline 538 to 290 μm (p < 0.001) and complete macular edema resolution was achieved in 51.0% of patients (56.3% and 42.5% in BRVO and CRVO patients, respectively). BCVA also improved (p < 0.01). Logistic regression analysis revealed a relationship between recurrence of macular edema and disorganization of retinal inner layers (DRIL) at baseline (odds ratio = 2.88; p = 0.013).

CONCLUSION:

Good long-term anatomical and functional outcomes are achieved with intravitreal treatments in RVO patients. Anatomical success and visual gains seen in the first year were maintained throughout the entire follow-up, though DRIL is a major risk factor for recurrence.

• Authors: Jorge Vasco Costa, Nuno Moura-Coelho, Ana Carolina Abreu, Pedro Neves, Mário Ornelas, Maria João Furtado
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 259 Issue 2 Pg. 343-350 (Feb 2021) ISSN: 1435-702X [Electronic] Germany
• PMID: 32965652 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Angiogenesis Inhibitors

Topics

• Angiogenesis Inhibitors (therapeutic use)
• Follow-Up Studies
• Humans
• Intravitreal Injections
• Macular Edema (diagnosis, epidemiology, etiology)
• Retinal Vein Occlusion (complications, diagnosis, epidemiology)
• Retrospective Studies
• Tomography, Optical Coherence
• Treatment Outcome
• Visual Acuity