Abstract | BACKGROUND: METHODS: We compared the short-term response rates of patients treated with high dosages of natural adrenocorticotropic hormone (120 IU/day) (N = 31) (Group1) with those of patients treated with low-moderate dosages of natural adrenocorticotropic hormone (40 IU/day) (N = 52) (Group2). We also compared the short-term response rates of patients treated with natural adrenocorticotropic hormone (N = 83) with those of patients treated with synthetic adrenocorticotropic hormone, (N = 23) (Group3). The responses were evaluated clinically and by electroencephalography at two to three weeks after the onset of therapy. RESULTS: A response was seen in 24 of 31 children treated with high dosages and in 43 of 52 children treated with low-moderate dosages of natural adrenocorticotropic hormone (P = 0.56). All children with an unknown etiology responded to both high and low-moderate dosages of natural adrenocorticotropic hormone. The proportion of children with a good early response to synthetic adrenocorticotropic hormone (16 of 23) did not differ from the proportion of children with a good early response treated with natural adrenocorticotropic hormone (67 of 83) (P = 0.25). CONCLUSIONS:
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Authors | Raili Riikonen, Jaana Lähdetie, Hannu Kokki |
Journal | Pediatric neurology
(Pediatr Neurol)
Vol. 111
Pg. 46-50
(10 2020)
ISSN: 1873-5150 [Electronic] United States |
PMID | 32951660
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Chemical References |
- Cosyntropin
- Adrenocorticotropic Hormone
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Topics |
- Adrenocorticotropic Hormone
(administration & dosage)
- Child, Preschool
- Cosyntropin
(administration & dosage)
- Electroencephalography
- Female
- Humans
- Infant
- Infant, Newborn
- Male
- Outcome Assessment, Health Care
- Retrospective Studies
- Spasms, Infantile
(drug therapy, physiopathology)
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