Peripartum management of a parturient with type 1C (clearance) von Willebrand disease.

Abstract

Peripartum replacement of factor VIII and von Willebrand factor is not usually required in type 1 von Willebrand disease, as the levels of endogenous factors tend to increase to within the normal range as a physiological change of pregnancy. However, there is wide heterogeneity of genotypes and phenotypes associated with type 1 von Willebrand disease. Here, we describe the anesthetic management of a parturient with type 1C von Willebrand disease, a subtype characterized by decreased plasma von Willebrand factor survival.

• Authors: C Prior, K Sims, K Seligman, S Jackson, A Chau
• Journal: International journal of obstetric anesthesia (Int J Obstet Anesth) Vol. 44 Pg. 112-115 (11 2020) ISSN: 1532-3374 [Electronic] Netherlands
• PMID: 32942216 (Publication Type: Case Reports)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Drug Combinations
• factor VIII, von Willebrand factor drug combination
• von Willebrand Factor
• Factor VIII

Topics

• Adult
• Analgesia, Epidural (methods)
• Analgesia, Obstetrical (methods)
• Drug Combinations
• Factor VIII (administration & dosage)
• Female
• Humans
• Peripartum Period
• Pregnancy
• Pregnancy Complications, Hematologic (physiopathology)
• von Willebrand Diseases (physiopathology)
• von Willebrand Factor (administration & dosage)