Beyond genes and transcription factors: A potential mechanism for the pathogenesis of cerebral cavernous malformations.

Abstract

In this issue of JEM, Hong et al. (https://doi.org/10.1084/jem.20200140) identify a major step in the pathogenesis of cerebral cavernous malformations (CCMs), which at the same time offers insight into potential therapy for this disease.

• Authors: William A Muller
• Journal: The Journal of experimental medicine (J Exp Med) Vol. 217 Issue 10 (10 05 2020) ISSN: 1540-9538 [Electronic] United States
• PMID: 32941595 (Publication Type: Journal Article, Comment)
• Copyright: © 2020 Muller.

Chemical References

• Transcription Factors
• Versicans
• ADAMTS5 Protein
• ADAMTS5 protein, human

Topics

• ADAMTS5 Protein
• Hemangioma, Cavernous, Central Nervous System (genetics)
• Humans
• Proteolysis
• Transcription Factors (genetics)
• Versicans