[Influence of phenazopyridine on the well-being of patients during and after cystoscopy].

Abstract

INTRODUCTION:

Cystoscopy is one of the most common procedures in urology. There is no single approach to pain relief. In the literature, there are conflicting data on the efficiency of intra-urethral gels. The use of non-steroidal anti-inflammatory drugs, intravenous sedation, and nitric oxide analgesia has been described. Phenazopyridine has been known for a long time. Acting on the bladder mucosa, it has a local analgesic effect. AN evaluation of phenazopyridine intake prior to cystoscopy in order to decrease pain during procedure and facilitate subsequent urination was performed.

MATERIALS AND METHODS:

A total of 97 patients were included in the study. Indications for cystoscopy were as following: hematuria, lower urinary tract symptoms/pain, a need to remove ureteral stent. The patients were randomized into two groups. In the main group (n=50), phenazopyridine 200 mg was administered 20 minutes before cystoscopy and then at a dose of 200 mg every 8 hours (in total three doses) in combination with lidocaine gel. In the control group (n=47), only lidocaine gel was used. Heart rate was measured before and after the procedure. All patients were asked to complete a visual analogue scale (VAS) 3, 8 and 24 hours after cystoscopy with the assessment of the first urination.

RESULTS:

After cystoscopy, the difference between groups in VAS score was 27.7% in favor of the main group (p<0.001). After 3 hours, the average score in the main group was two times less than in the Control (p=0.012), while 3 and 8 hours after cystoscopy, the proportion of "zero" results was 10% and 0%, 28% and 4%, respectively, p<0.005. The heart rate after the procedure in the main group was 75.1 beats/min, compared to 77.9 beats/min in the control group (p=0.016).

CONCLUSION:

The intake of phenazopyridine allows to reduce pain intensity during and after cystoscopy and alleviate pain during first urination.

• Authors: A Yu Tsukanov, D G Makushin, A A Mirzakadiev, I A Zolotov
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) Issue 4 Pg. 50-54 (Sep 2020) ISSN: 1728-2985 [Print] Russia (Federation)
• PMID: 32897014 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Phenazopyridine

Topics

• Cystoscopy (adverse effects)
• Humans
• Pain
• Phenazopyridine (therapeutic use)
• Ureter