Clinical outcomes of KeraVio using violet light: emitting glasses and riboflavin drops for corneal ectasia: a pilot study.

Abstract

BACKGROUND/AIMS:

We developed a novel technology consisting of violet light (VL)-emitting glasses and defined the combination of VL irradiation and riboflavin treatment as KeraVio. Our goal was to evaluate the clinical results of KeraVio in patients with progressive corneal ectasia.

METHODS:

Eyes were exposed to VL (375 nm, irradiance 310 μW/cm2)-emitting glasses for 3 hours daily for 6 months, and a riboflavin solution was administered onto the corneal epithelium six times during each 3-hour VL irradiation. The primary end point was a change in the maximum keratometry (Kmax) value over 6 months compared with that over the 1 year before baseline.

RESULTS:

The efficacy of KeraVio was evaluated in 20 eyes with severe progression, and its safety was evaluated in all 40 eyes. The mean changes in Kmax over the 1 year before baseline and during the 6-month observation period were 6.03±3.41 dioptres (D) and -0.81±3.34 D, respectively (p=0.002). At 6 months, the Kmax value decreased by more than 2 D in 4 eyes (20%), remained within 2 D in 13 eyes (65%), and increased by 2 D or more in 3 eyes (15%). The corneal stromal demarcation line was identified in 16 eyes (80%), and its depth was 206.3±54.9 μm at 1 month. No significant decrease in endothelial cell density, lenticular opacity or transient corneal haze was noted.

CONCLUSION:

Based on our 6-month results, daily treatment of progressive corneal ectasia with KeraVio can halt disease progression without any safety concerns.

CLINICAL TRIAL REGISTRATION NUMBER:

jRCTs032180217.

• Authors: Hidenaga Kobashi, Hidemasa Torii, Ikuko Toda, Shinichiro Kondo, Motozumi Itoi, Kazuo Tsubota
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 105 Issue 10 Pg. 1376-1382 (10 2021) ISSN: 1468-2079 [Electronic] England
• PMID: 32892163 (Publication Type: Journal Article)
• Copyright: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Chemical References

• Cross-Linking Reagents
• Photosensitizing Agents
• Collagen
• Riboflavin

Topics

• Collagen (therapeutic use)
• Corneal Topography
• Cross-Linking Reagents (therapeutic use)
• Dilatation, Pathologic (drug therapy)
• Humans
• Keratoconus (drug therapy)
• Photochemotherapy
• Photosensitizing Agents (therapeutic use)
• Pilot Projects
• Riboflavin (therapeutic use)
• Ultraviolet Rays
• Visual Acuity