Abstract | OBJECTIVES: Repeated exposure to anoxic stress damages the brain through cortisol-mediated increases in oxidative stress and cellular- antioxidants depletion. Thus, compounds with antioxidant property might confer protection against anoxic stress-induced brain injuries. In this study, we further examined the protective effect of methyl jasmonate (MJ), a potent anti-stress agent against anoxic stress-induced convulsions in mice. METHODS: Thirty-six male Swiss mice randomized into six groups (n=6) were given MJ (25, 50 and 100 mg/kg, i.p.) or vehicle (10 mL/kg, i.p.) 30 min before 15 min daily exposure to anoxic stress for 7 days. The latency(s) to anoxic convulsion was recorded on day 7. The blood glucose and serum corticosterone levels were measured afterwards. The brains were also processed for the determination of malondialdehyde, nitrite, and glutathione levels. RESULTS: CONCLUSIONS: These findings further showed that MJ possesses anti-stress property via mechanisms relating to the reduction of serum contents of corticosterone and normalization of brain biomarker levels of oxidative stress in mice with anoxic stress.
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Authors | Abayomi Ololade Adelaja, Oluwafemi Gabriel Oluwole, Oritoke Modupe Aluko, Solomon Umukoro |
Journal | Drug metabolism and personalized therapy
(Drug Metab Pers Ther)
Vol. 35
Issue 4
(09 04 2020)
ISSN: 2363-8915 [Electronic] Germany |
PMID | 32887181
(Publication Type: Journal Article)
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Copyright | © 2020 Walter de Gruyter GmbH, Berlin/Boston. |
Chemical References |
- Acetates
- Antioxidants
- Biomarkers
- Cyclopentanes
- Oxylipins
- methyl jasmonate
- Corticosterone
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Topics |
- Acetates
- Animals
- Antioxidants
(pharmacology)
- Biomarkers
(metabolism)
- Brain
- Corticosterone
(pharmacology)
- Cyclopentanes
- Humans
- Male
- Mice
- Oxidative Stress
- Oxylipins
- Seizures
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