Retinal layers and visual conductivity changes in a case series of microangiopathic ischemic stroke patients.

Abstract

BACKGROUND:

It is unknown whether microangiopathic ischemic strokes outside the visual pathway go along with subclinical changes of the retinal structure or the visual system. The objectives of this prospective non-interventional case series were to investigate if spectral-domain optical coherence tomography (SD-OCT) or multifocal visual evoked potentials (mfVEPs) can detect structural retinal changes or functional impairment of the visual system in patients with microangiopathic ischemic stroke.

METHODS:

We used SD-OCT to cross-sectionally analyze the retinal morphology of 15 patients with microangiopathic ischemic stroke according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification not affecting the visual pathway. We employed semi-automated segmentation of macular volume scans to analyze the thickness of the macular retinal layers and peripapillary ring scans to investigate the retinal morphology in comparison to a control group without stroke. Visual function was assessed by the mfVEP technique in 13 microangiopathic ischemic stroke patients.

RESULTS:

First peak latency of mfVEPs was significantly delayed in the microangiopathic ischemic stroke group compared to the control patients. Neither the retinal layers nor the mfVEPs' amplitude differed between the microangiopathic ischemic stroke patients and the control group.

CONCLUSIONS:

In conclusion, microangiopathic ischemic stroke patients presented a delayed first peak latency in mfVEPs as a sign of subclinical functional impairment of the visual pathway. However, our case series suggests no influence on retinal structure resulting from microangiopathic ischemic stroke outside the visual system. Larger and longitudinal studies are needed to confirm these mfVEP findings.

• Authors: John-Ih Lee, Lena Gemerzki, Margit Weise, Laura Boerker, Jonas Graf, Lea Jansen, Rainer Guthoff, Orhan Aktas, Michael Gliem, Sebastian Jander, Hans-Peter Hartung, Philipp Albrecht
• Journal: BMC neurology (BMC Neurol) Vol. 20 Issue 1 Pg. 333 (Sep 03 2020) ISSN: 1471-2377 [Electronic] England
• PMID: 32883246 (Publication Type: Journal Article)

Topics

• Aged
• Brain Ischemia (physiopathology)
• Evoked Potentials, Visual
• Female
• Humans
• Male
• Middle Aged
• Prospective Studies
• Retina (diagnostic imaging)
• Stroke (physiopathology)
• Tomography, Optical Coherence (methods)
• Visual Field Tests
• Visual Pathways (physiopathology)