In this study, we synthesised the
zinc oxide nanoparticles from Vernonia amygdalina and evaluated its anti-inflammatory and antinociceptive potentials against the different
inflammation and
pain induced mice model. The synthesised
zinc oxide nanoparticles were characterised by UV, SEM, XRD and FTIR techniques. The anti-nociceptive effects of V. amygdalina were examined by different stimuli e.g.
acetic acid,
glutamate,
capsaicin, and
formalin-induced nociception in mice. The anti-inflammatory effects of synthesised
zinc oxide nanoparticles were assessed by air sack assessment and the level of inflammatory
cytokines were studied. The muscle tension of animals were studied through open field assessment. The present study exhibited proficient antinociceptive and anti-inflammatory actions of the synthesised
Zinc oxide nanoparticles from V. amygdalina. The sormulated
zinc oxide nanoparticles were appreciably reduced the
acetic acid,
glutamate,
capsaicin, and
formalin-induced nociceptive responses in mice. Further the
zinc nanoparticles were exhibited the potent anti-inflammatory actions via reducing the inflammatory response and pro-inflammatory
cytokines level in the mice. In conclusion, the findings of this study proved the beneficial effects of
zinc oxide nanoparticles from V. amygdalina against the different
pain and
inflammation-induced mice. Hence, it was clear that the
zinc nanoparticles from V. amygdalina could be promising antinociceptive and
anti-inflammatory agent in the future.