Abstract | PURPOSE: METHODS: RESULTS: 120 subjects were enrolled and 112 completed the trial. Subjects had an average age (SD) of 39.31 (14.5) years; 67% of subjects were female. Overall baseline means (SD) were 81.2 (25.6) for number of bleeding sites and 1.51 (0.197) for mean LSGI score. Baseline disease levels were balanced across all treatment groups. At Week 2, SnF2 dentifrices A and B demonstrated a significant reduction in gingival bleeding sites versus the negative control; however, SnF2 dentifrice C was not significantly different from the negative control (P= 0.15). At Weeks 4 and 12, all SnF2 dentifrices demonstrated a significant gingival bleeding site reduction versus the negative control (P< 0.001). At Weeks 2, 4 and 12, the SnF2 dentifrices were rank ordered dentifrice A > dentifrice B > dentifrice C for reduction in gingival bleeding sites (P< 0.001). The same trends were seen for LSGI scores. CLINICAL SIGNIFICANCE: In this 12-week clinical study, all 0.454% SnF2 dentifrices delivered statistically significant reductions in the number of gingival bleeding sites relative to the negative control. Importantly, statistically significant efficacy differences were observed among the three 0.454% SnF2 dentifrices, demonstrating the important role that differences in formulation have on clinical efficacy.
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Authors | Tao He, Sushma Nachnani, Steve Lee, Yuanshu Zou, Julie Grender, Svetlana Farrell, Paul Sagel, Aaron R Biesbrock |
Journal | American journal of dentistry
(Am J Dent)
Vol. 33
Issue 4
Pg. 218-224
(Aug 2020)
ISSN: 0894-8275 [Print] United States |
PMID | 32794398
(Publication Type: Clinical Trial, Randomized Controlled Trial)
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Copyright | Copyright©American Journal of Dentistry. |
Chemical References |
- Dentifrices
- Tin Fluorides
- Sodium Fluoride
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Topics |
- Adult
- Dental Plaque
- Dental Plaque Index
- Dentifrices
- Double-Blind Method
- Female
- Gingivitis
- Humans
- Sodium Fluoride
- Tin Fluorides
- Treatment Outcome
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