Abstract | BACKGROUND: METHODS: We performed a single-center, randomized, placebo-controlled, double-blinded study. Trauma patients who were ≥65 years old and had ≥1 rib fracture were included in this study. Patients were randomized into IV acetaminophen and oral placebo (n = 63) or IV placebo and oral solution acetaminophen (n = 75) groups. The primary outcome was a mean reduction in pain score at 24 hours, and secondary outcomes included opioid use, intensive care unit (ICU) length of stay (LOS), hospital LOS, hospital mortality, the difference in incentive spirometry, and development of pneumonia. RESULTS: Among the 138 patients included, there was no statistically significant difference between the 2 study groups in a mean reduction in pain score at 24 hours after injury (PO: 3.24, IV: 2.49; P = .230). Opioid pain medication use was equivalent between groups (P = .212), and there was no significant difference in hospital mortality rate between groups (P = .827). There was no statistically significant difference in ICU LOS, hospital LOS, or development of pneumonia. DISCUSSION:
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Authors | Andrew C Antill, Sarah W Frye, James C McMillen, James C Haynes, Benjamin R Ford, Reagan W Bollig, Brian J Daley |
Journal | The American surgeon
(Am Surg)
Vol. 86
Issue 8
Pg. 926-932
(Aug 2020)
ISSN: 1555-9823 [Electronic] United States |
PMID | 32749863
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Non-Narcotic
- Acetaminophen
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Topics |
- Acetaminophen
(administration & dosage, therapeutic use)
- Acute Pain
(drug therapy, etiology)
- Administration, Intravenous
- Administration, Oral
- Aged
- Aged, 80 and over
- Analgesics, Non-Narcotic
(administration & dosage, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Male
- Musculoskeletal Pain
(drug therapy, etiology)
- Prospective Studies
- Rib Fractures
(complications)
- Treatment Outcome
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