Transverse myelitis as a rare presentation of antiphospholipid-antibody-associated disorders.

Abstract

We report the case of a 35-year-old male patient suffering from a clinical and radiological manifestation of a transverse myelitis associated with antiphospholipid antibodies. After a challenging diagnosis the patient improved substantially due to immunosuppressive treatment. The demyelinating spinal cord lesion and the impressive therapeutic outcome may support the possibility of a direct binding of antiphospholipid antibodies to CNS antigens and consequently leading to a neuroimmunological pathomechanism distinct from the well-known pro-thrombotic effect of antiphospholipid antibodies. In terms of clinical routine diagnostic this case report highlights a rare but notable differential diagnosis of Multiple Sclerosis-like syndromes.

• Authors: Klaus Berek, Elena Fava, Anne Zinganell, Harald Hegen, Michael Auer, Sebastian Wurth, Paul Rhomberg, Florian Deisenhammer, Franziska Di Pauli
• Journal: Multiple sclerosis and related disorders (Mult Scler Relat Disord) Vol. 45 Pg. 102405 (Oct 2020) ISSN: 2211-0356 [Electronic] Netherlands
• PMID: 32707532 (Publication Type: Case Reports)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Antibodies, Antiphospholipid
• Immunosuppressive Agents

Topics

• Adult
• Antibodies, Antiphospholipid
• Diagnosis, Differential
• Humans
• Immunosuppressive Agents
• Male
• Multiple Sclerosis
• Myelitis, Transverse (diagnostic imaging, drug therapy)