Burosumab in X-linked hypophosphatemia and perspective for chronic kidney disease.

Abstract

PURPOSE OF REVIEW:

Perturbations in phosphate and vitamin D homeostasis impacts skeletal health in children and adults. Study of inherited and acquired hypophosphatemic syndromes led to the discovery of fibroblast growth factor 23 (FGF23) as a potent regulator of phosphate and vitamin D metabolism, and advanced our understanding of the pathophysiology of mineral and bone disorder in chronic kidney disease (CKD-MBD). Here, we review a recently approved therapy for patients with X-linked hypophosphatemia (XLH) using a novel anti-FGF23 antibody, burosumab, and discuss the implications of such targeted therapy in CKD.

RECENT FINDINGS:

In children and adults with XLH, burosumab treatment significantly increased renal tubular phosphate reabsorption and normalized serum phosphorus concentrations. Prolonged treatment with burosumab showed a favorable safety profile, improved healing of rickets in children, and fractures and pseudofractures in adults. FGF23 excess in CKD is independently associated with left ventricular hypertrophy and cardiovascular mortality. Research strategies to lower FGF23 in animal models of CKD are rapidly advancing and a question that remains to be answered is whether FGF23 blockade will offer a new targeted intervention for disordered mineral metabolism in CKD.

SUMMARY:

Findings from recently concluded clinical trials in adults and children with XLH provide evidence for improved skeletal health with burosumab therapy with normalization of phosphate and vitamin D metabolism. Targeted anti-FGF23 antibody treatment of XLH has emerged as a novel therapeutic strategy to treat an inherited disorder of FGF23 excess.

• Authors: Shanthi Balani, Farzana Perwad
• Journal: Current opinion in nephrology and hypertension (Curr Opin Nephrol Hypertens) Vol. 29 Issue 5 Pg. 531-536 (09 2020) ISSN: 1473-6543 [Electronic] England
• PMID: 32701599 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Monoclonal, Humanized
• FGF23 protein, human
• Phosphates
• Vitamin D
• Fibroblast Growth Factors
• Fibroblast Growth Factor-23
• burosumab

Topics

• Animals
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Familial Hypophosphatemic Rickets (drug therapy, metabolism)
• Fibroblast Growth Factor-23
• Fibroblast Growth Factors (antagonists & inhibitors)
• Humans
• Phosphates (metabolism)
• Renal Insufficiency, Chronic (metabolism)
• Vitamin D (metabolism)