Abstract | PURPOSE:
Visfatin is a key cytokine released from the pe ripheral blood mononuclear cells (PBMCs) as well as adipose tissue, and it is involved in immune response as well as inflammation. In this study, we investigated whether the serum visfatin level could be a prognostic factor for predicting the severity of inflammation in patients with acute cholecystitis. METHODS: We examined the blood samples and gallbladder specimens from patients who underwent laparoscopic cholecystectomy for either acute (n = 18) or chronic cholecystitis (n = 18). We determined the visfatin levels of these samples using various procedures such as real-time polymerase chain reaction, enzyme-linked immunosorbent assay, western blotting, and immunohistochemistry. RESULTS: CONCLUSION: Taken together, we concluded that visfatin is a pro-inflammatory mediators that is upregulated during acute cholecystitis and is expected to be increased within a short time after inflammation. Therefore, measuring the serum level of visfatin would be helpful in predicting the inflammatory severity in the patients with acute cholecystitis.
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Authors | Jae Woo Park, Ok-Hee Kim, Sang Chul Lee, Kee-Hwan Kim, Ha-Eun Hong, Haeyeon Seo, Ho Joong Choi, Say-June Kim |
Journal | Annals of surgical treatment and research
(Ann Surg Treat Res)
Vol. 99
Issue 1
Pg. 26-36
(Jul 2020)
ISSN: 2288-6575 [Print] Korea (South) |
PMID | 32676479
(Publication Type: Journal Article)
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Copyright | Copyright © 2020, the Korean Surgical Society. |