Abstract | OBJECTIVE: To compare the efficacy of domestic and imported caffeine citrate in the treatment of apnea in preterm infants. METHODS: A total of 98 preterm infants with a gestational age of 28 - <34 weeks between April 2018 and December 2019 were enrolled. They were randomly administered with domestic (n=48) or imported caffeine citrate (n=50) within 6 hours after birth. The therapeutic effects, complications, adverse effects and clinical outcomes were compared between the two groups. RESULTS: There were no significant differences in the incidence of apnea within 7 days after birth, daily frequency of apnea, the time of apnea disappearance, the failure rate of intubation- surfactant-extubation strategy, the time of non-invasive assisted ventilation, the duration of oxygen therapy, the duration of caffeine citrate therapy, the length of hospital stay, blood gas analysis results, liver and kidney function testing results between the two groups (P>0.05). There were no significant differences in the incidence of complications and the mortality rate between the two groups (P>0.05). There was no significant difference in the incidence of adverse effects between the two groups (P>0.05). CONCLUSIONS:
|
Authors | Ting He, Zheng-Chang Liao, Ying Ding, Ming-Jie Wang, Wen Li, Ji-Min Gan, Shao-Jie Yue |
Journal | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
(Zhongguo Dang Dai Er Ke Za Zhi)
Vol. 22
Issue 7
Pg. 684-689
(Jul 2020)
ISSN: 1008-8830 [Print] China |
PMID | 32669161
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Citrates
- Caffeine
- caffeine citrate
|
Topics |
- Apnea
(drug therapy)
- Caffeine
(therapeutic use)
- Citrates
(therapeutic use)
- Double-Blind Method
- Humans
- Infant
- Infant, Newborn
- Infant, Premature
- Infant, Premature, Diseases
- Prospective Studies
|