Abstract | INTRODUCTION: METHODS: In the present study, 21 male individuals with MAUD, 21 demographically matched individuals with HUD, and 21 normal controls (NC) were recruited. The amplitude of low-frequency fluctuation (ALFF) during resting-state brain function was measured by magnetic resonance imaging. Psychiatric status was evaluated by the Symptom Checklist-90 (SCL90). RESULTS: Individuals with MAUD had increased SCL90 scores compared to those of the NC for anxiety, paranoia, and additional items, and the hostility score was significantly increased compared to that of individuals with HUD. There is no significant difference between HUD and NC individuals. Individuals with MAUD had increased ALFF compared to those of the NC for thalamus, right postcentral, and right inferior temporal gyri, but a decreased ALFF in the cerebellum. Individuals with HUD had significantly increased ALFF compared to those of the NC for left middle frontal gyrus but a decreased ALFF in the left postcentral gyrus. Individuals with MAUD had significantly increased ALFF compared to those of the HUD for thalamus, the right inferior temporal, and bilateral postcentral gyri, and the ALFF of cerebellum and left middle frontal was significantly increased. CONCLUSIONS:
Methamphetamine can induce more serious psychiatric disorders than heroin. The resting-state function involved in mood adjustment, the auditory, and memory-related brain regions may affect psychotic symptoms related to MAUD.
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Authors | Yan Liu, Jia Zhu, Qiang Li, Yarong Wang, Yongbin Li, Jiajie Chen, Shan Dang, Jing Chen, Hong Shi, Jiuhua Xue, Wei Li, Wei Wang |
Journal | Brain and behavior
(Brain Behav)
Vol. 10
Issue 9
Pg. e01703
(09 2020)
ISSN: 2162-3279 [Electronic] United States |
PMID | 32666687
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC. |
Chemical References |
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Topics |
- Brain
- China
- Heroin
- Humans
- Magnetic Resonance Imaging
- Male
- Methamphetamine
(adverse effects)
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