Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-κB signaling pathway inhibition.

Abstract

It has been established that poor outcomes in ischemic stroke patients are associated with the post-reperfusion inflammatory response and up-regulation of TLR4. Therefore, suppression of the TLR4 signaling pathway constitutes a potential neuroprotective therapeutic strategy. Schisandrin B, a compound extracted from Schisandra chinensis, has been shown to possess anti-inflammatory and neuroprotective properties. However, the mechanism remains unclear. In the present study, the therapeutic effect of schisandrin B was assessed following cerebral ischemia and reperfusion (I/R) injury in a model of middle cerebral artery occlusion and reperfusion (MCAO/R) in rats. The effects of schisandrin B were investigated with particular emphasis on TLR4 signal transduction and on the inflammatory response. Schisandrin B treatment conferred significant protection against MCAO/R injury, as evidenced by decreases in infarct volume, neurological score, and the number of apoptotic neurons and inflammatory signaling molecules.

ABBREVIATIONS:

I/R: schemia/reperfusion; IL: interleukin; MCAO/R: middle cerebral artery occlusion and reperfusion; NF-κB: nuclear; TLR4: Toll-like receptor 4; TNF-α: tumor necrosis factor-α.

• Authors: Xingjuan Fan, Kenneth Elkin, Yunwei Shi, Zhihong Zhang, Yaqin Cheng, Jingxiao Gu, Jiale Liang, Caiping Wang, Xunming Ji
• Journal: Neurological research (Neurol Res) Vol. 42 Issue 8 Pg. 693-702 (Aug 2020) ISSN: 1743-1328 [Electronic] England
• PMID: 32657248 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Cyclooctanes
• Lignans
• NF-kappa B
• Polycyclic Compounds
• Tlr4 protein, rat
• Toll-Like Receptor 4
• schizandrin B

Topics

• Animals
• Anti-Inflammatory Agents (administration & dosage)
• Brain Ischemia (complications, metabolism, prevention & control)
• Cyclooctanes (administration & dosage)
• Lignans (administration & dosage)
• Male
• NF-kappa B (metabolism)
• Polycyclic Compounds (administration & dosage)
• Rats, Sprague-Dawley
• Reperfusion Injury (complications, metabolism, prevention & control)
• Signal Transduction (drug effects)
• Toll-Like Receptor 4 (metabolism)