Role of polymorphisms of the endothelial nitric oxide synthase gene in predicting slow-flow phenomenon after primary percutaneous coronary intervention.

Abstract

OBJECTIVE:

The aim of the present study was to examine the association between 2 polymorphisms of the endothelial nitric oxide (eNOS) gene (-786T>C and +894G>T) and the no-reflow/slow-flow phenomenon in post-primary percutaneous coronary intervention (PPCI) patients.

METHODS:

A total of 103 post-PPCI patients were enrolled. Coronary no-reflow phenomenon was defined as a Thrombolysis in Myocardial Infarction (TIMI) flow grade 0-1 and coronary slow-flow phenomenon (CSFP) was defined as a TIMI flow grade ≤2.

RESULTS:

Due to the small number of post-PPCI patients with the no-reflow phenomenon (n=4), the primary comparison was made between CSFP (n=20) and normal flow (n=83) groups. There was a greater frequency of CSFP among carriers of the -786C allele of the eNOS -786T>C polymorphism (odds ratio [OR]: 3.90; 95% confidence interval [CI]: 0.87-17.45; p=0.07). However, no such association was detected between the +894T allele of the eNOS +894G>T and CSFP (OR: 0.92; 95% CI: 0.21-3.98; p=0.91). In the adjusted analysis, the -786T>C polymorphism did not reach statistical significance.

CONCLUSION:

There was no significant association between CSFP and 2 of the most common polymorphisms of the eNOS gene in post-PPCI patients.

• Authors: Reza Kiani, Sanam Alilou, Shirin Rafatnia, Yasaman Taslimi, Sima Habibzadeh, Safoora Gharibzadeh, Ata Firouzi, Shahin Rahim, Ali Zahedmehr, Farzaneh Mehrvarz, Mehrdad Moghadam Ahari, Parham Sadeghipour
• Journal: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir (Turk Kardiyol Dern Ars) Vol. 48 Issue 5 Pg. 472-483 (07 2020) ISSN: 1308-4488 [Electronic] Turkey
• PMID: 32633262 (Publication Type: Journal Article)

Chemical References

• NOS3 protein, human
• Nitric Oxide Synthase Type III

Topics

• Alleles
• Confidence Intervals
• Coronary Angiography
• Coronary Circulation (physiology)
• Cross-Sectional Studies
• Female
• Humans
• Male
• Middle Aged
• Nitric Oxide Synthase Type III (genetics)
• No-Reflow Phenomenon (genetics)
• Odds Ratio
• Percutaneous Coronary Intervention
• Polymorphism, Single Nucleotide
• Prospective Studies
• ST Elevation Myocardial Infarction (diagnostic imaging, genetics, therapy)
• Time-to-Treatment