Clinical application of target temperature management in children with acute encephalopathy-A practical review.

Abstract

Acute encephalopathy is a life-threatening disease involving acute brain dysfunction, and it is one of the most important causes of mortality and severe neurological sequelae in infants and children. Approximately 30% of cases of acute encephalopathy result in some degree of neurological sequelae. Although many strategies have been proposed, effective therapies to ameliorate the outcomes of acute encephalopathy have not yet been established. Target temperature management (TTM), previously termed therapeutic hypothermia, has been shown to be effective for various brain injuries due to multiple neuroprotective mechanisms, and it may be considered to be the cornerstone of neuroprotective strategies. Consequently, TTM is currently used in the neurocritical care of adult patients with cardiac arrest with shockable rhythm and perinatal asphyxia. In addition, increasing evidence also indicates that TTM could be useful in other acute encephalopathies, including status epilepticus, acute encephalitis/encephalopathy and traumatic brain injury. In this review, we discuss the recent practical aspects of TTM as a potential intervention for various acute encephalopathies in children.

• Authors: Jainn-Jim Lin, Shao-Hsuan Hsia, Ming-Chou Chiang, Kuang-Lin Lin
• Journal: Biomedical journal (Biomed J) Vol. 43 Issue 3 Pg. 211-217 (06 2020) ISSN: 2320-2890 [Electronic] United States
• PMID: 32611538 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Chang Gung University. Published by Elsevier B.V. All rights reserved.

Topics

• Humans
• Hypothermia, Induced
• Neurodegenerative Diseases
• Prospective Studies
• Retrospective Studies
• Temperature