Abstract | PURPOSE: METHODS: The VK1 ointment was applied to one-half of an affected area and placebo ointment was applied to the other half twice a day for 8 weeks, with photography and clinical evaluation being performed every 2 weeks. The primary endpoint was the change of the VK1/placebo ratio for the number of acneiform eruptions counted by an independent dermatologist between the onset and end of the treatment period. RESULTS: A total of 30 patients were enrolled. The mean VK1/placebo ratio for the number of acneiform eruptions between the onset and end of the treatment period was -0.158±0.680 and 0.146±0.575, respectively, which was not statistically significant(p=0.069). The mean number of acneiform eruptions at each treatment period at the VK1 and placebo application sites was gradually decreased according to the treatment period. CONCLUSION:
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Authors | Hironobu Hashimoto, Satoru Iwasa, Takako Yanai-Takahashi, Yoshitaka Honma, Ken Kato, Tetsuya Hamaguchi, Yasuhide Yamada, Yasuhiro Shimada, Naoya Yamazaki, Yasuhisa Kato |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 47
Issue 6
Pg. 933-939
(Jun 2020)
ISSN: 0385-0684 [Print] Japan |
PMID | 32541171
(Publication Type: Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antineoplastic Agents
- Ointments
- Panitumumab
- Vitamin K 1
- Cetuximab
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Topics |
- Acneiform Eruptions
(chemically induced)
- Antineoplastic Agents
(adverse effects)
- Cetuximab
(adverse effects)
- Double-Blind Method
- Humans
- Ointments
- Panitumumab
(adverse effects)
- Vitamin K 1
(therapeutic use)
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