[Effectiveness of corticoid pulses in patients with cytokine storm syndrome induced by SARS-CoV-2 infection].

Abstract

INTRODUCTION:

Cytokine storm syndrome (CSS) is a serious complication of COVID-19 patients. Treatment is tocilizumab. The use of glucocorticoids (GC) is controversial. In other very similar CSS, such as macrophage activation syndrome (MAS) and hemophagocytic syndrome (HFS), the main treatment are corticosteroids. Our objective is to evaluate the efficacy of GC in the CSS by COVID-19.

PATIENTS:

We included 92 patients with CSS associated to COVID-19 who received GC, GC, and tocilizumab and only tocilizumab. We determine CSS markers. We evaluated mortality, intubation, and a combined variable.

RESULTS:

In all cases the percentages of events were lower in the group of patients with GC was administered. The hazard ratio of the final variables with GC versus the group in which only tocilizumab was administered was lower as CGs were considered, with statistical significance for survival.

DISCUSSION:

The early use of GC pulses could control SLC, with a lower requirement to use tocilizumab and a decrease in events such as intubation and death.

• Authors: José Luis Callejas Rubio, Juan de Dios Luna Del Castillo, Javier de la Hera Fernández, Emilio Guirao Arrabal, Manuel Colmenero Ruiz, Norberto Ortego Centeno
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 155 Issue 4 Pg. 159-161 (08 28 2020) ISSN: 1578-8989 [Electronic] Spain
• Vernacular Title: Eficacia de los pulsos de corticoides en pacientes con síndrome de liberación de citocinas inducido por infección por SARS-CoV-2.
• PMID: 32532461 (Publication Type: Case Reports, Observational Study)
• Copyright: Copyright © 2020 Elsevier España, S.L.U. All rights reserved.

Chemical References

• Adrenal Cortex Hormones
• Antibodies, Monoclonal, Humanized
• tocilizumab

Topics

• Adrenal Cortex Hormones (administration & dosage)
• Adult
• Aged
• Aged, 80 and over
• Antibodies, Monoclonal, Humanized (administration & dosage)
• Betacoronavirus
• COVID-19
• Coronavirus Infections (complications, immunology, mortality)
• Cytokine Release Syndrome (drug therapy, etiology, mortality)
• Drug Administration Schedule
• Female
• Humans
• Intubation, Intratracheal (statistics & numerical data)
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Pandemics
• Pneumonia, Viral (complications, immunology, mortality)
• Retrospective Studies
• SARS-CoV-2