Abstract | BACKGROUND AND OBJECTIVE: METHODS: RESULTS: The synthesized compounds structures were discussed and confirmed depending on their spectral data. The anticancer activity of these heterocyclic compounds was evaluated against the breast cancer cell line (MCF-7), where they showed variable activity. Compound 5d found to have a superior anticancer activity, where it has (IC50 = 2.07 ± 0.13 μg/mL) in comparison with the reference drug doxorubicin that has (IC50 = 2.79 ± 0.07 μg / mL). Then compound 5d subjected to further studies such as cell cycle analysis and apoptosis. Apoptosis was confirmed by the upregulation of Bax, downregulation of Bcl-2, and the increase of the caspase 3/7percentage. CONCLUSION:
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Authors | Heba A Elhady, Hossa F Al-Shareef |
Journal | Mini reviews in medicinal chemistry
(Mini Rev Med Chem)
Vol. 20
Issue 18
Pg. 1929-1941
( 2020)
ISSN: 1875-5607 [Electronic] Netherlands |
PMID | 32525773
(Publication Type: Journal Article)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- Antineoplastic Agents
- DNA, Neoplasm
- Thiohydantoins
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Topics |
- Antineoplastic Agents
(chemical synthesis, chemistry, pharmacology)
- Apoptosis
(drug effects)
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- DNA, Neoplasm
(analysis)
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Flow Cytometry
- Humans
- MCF-7 Cells
- Molecular Structure
- Structure-Activity Relationship
- Thiohydantoins
(chemical synthesis, chemistry, pharmacology)
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