Effects of stannic chloride on human leucocytes in vitro.

Abstract

Single dose treatment with stannic chloride (4 micrograms/ml) on human lymphocytes in vitro revealed a significant increase of chromosomal aberrations. These showed a distinct relationship with the donor's age. Single and isochromatid breaks including gaps, premature chromosome condensation, irregular staining, stretching of the centromere and interchange, i.e. quadriradial exchange of chromosome arms, and also aneuploidy, were observed.

• Authors: B B Ghosh, G Talukder, A Sharma
• Journal: Cytobios (Cytobios) Vol. 56 Issue 224 Pg. 23-7 ( 1988) ISSN: 0011-4529 [Print] England
• PMID: 3251679 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tin Compounds
• stannic chloride
• Tin

Topics

• Dose-Response Relationship, Drug
• Female
• Humans
• Leukocytes (cytology, drug effects)
• Male
• Mitotic Index (drug effects)
• Tin (pharmacology)
• Tin Compounds