Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF-κB-mediated anti-apoptotic potential in glioblastoma.

Abstract

Glioblastoma is the most common primary brain tumor with poor survival rate and without effective treatment strategy. Notably, amplification and active mutation of epidermal growth factor receptor (EGFR) occur frequently in glioblastoma patient that may be a potential treatment target. Several studies indicated that various type of herbal compounds not only regulate anti-depressant effect but also shown capacity to suppress glioblastoma growth via inducing apoptosis and inhibiting oncogene signaling transduction. Hyperforin, an herb compound derived from St. John's wort was used to treat depressive disorder by inhibiting neuronal reuptake of several neurotransmitters. Although hyperforin can reduce matrix metallopeptidases-2 (MMPs) and -9-mediated metastasis of glioblastoma, the detail mechanism of hyperforin on glioblastoma is remaining unclear. Here, we suggested that hyperforin may induce extrinsic/intrinsic apoptosis and suppress anti-apoptotic related proteins expression of glioblastoma. We also indicated that hyperforin-mediated anti-apoptotic potential of glioblastoma was correlated to inactivation of EGFR/extracellular signal-regulated kinases (ERK)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling.

• Authors: Fei-Ting Hsu, Wei-Ting Chen, Ching-Te Wu, Jing-Gung Chung
• Journal: Environmental toxicology (Environ Toxicol) Vol. 35 Issue 10 Pg. 1058-1069 (Oct 2020) ISSN: 1522-7278 [Electronic] United States
• PMID: 32485087 (Publication Type: Journal Article)
• Copyright: © 2020 Wiley Periodicals LLC.

Chemical References

• Antineoplastic Agents, Phytogenic
• Apoptosis Regulatory Proteins
• RELA protein, human
• Terpenes
• Transcription Factor RelA
• Phloroglucinol
• EGFR protein, human
• ErbB Receptors
• Extracellular Signal-Regulated MAP Kinases
• hyperforin

Topics

• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Apoptosis (drug effects)
• Apoptosis Regulatory Proteins (metabolism)
• Brain Neoplasms (metabolism, pathology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• ErbB Receptors (metabolism)
• Extracellular Signal-Regulated MAP Kinases (metabolism)
• Glioblastoma (metabolism, pathology)
• Humans
• Hypericum (chemistry)
• Phloroglucinol (analogs & derivatives, isolation & purification, pharmacology)
• Signal Transduction
• Terpenes (isolation & purification, pharmacology)
• Transcription Factor RelA (genetics, metabolism)