Calixarene-mediated assembly of water-soluble C60-attached ultrathin graphite hybrids for efficient activation of reactive oxygen species to treat neuroblastoma cells.

Abstract

Unprecedented nano-carbon hybrids consisting of exfoliated ultrathin graphite (or single-walled carbon nanotubes) with pristine C60 molecules attached on the surfaces have been produced in water in the presence of p-phosphonic acid calix[8]arene. The amphiphilic calixarene plays multiple roles in these processes to provide water dispersibility and π-π interactions with flexible conformations complementing curvatures of the carbon surfaces. The significantly increased water solubility and area of exposure of C60 enable efficient activation of reactive oxygen species for enhanced phototoxicity to SH-SY5Y human neuroblastoma cell line under laser irradiation.

• Authors: Jingxin Mo , Meiying Li , Xianjue Chen , Qinghua Li
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 56 Issue 53 Pg. 7325-7328 (Jul 07 2020) ISSN: 1364-548X [Electronic] England
• PMID: 32478761 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Fullerenes
• Nanotubes, Carbon
• Phosphorous Acids
• Reactive Oxygen Species
• Water
• Calixarenes
• phosphonic acid
• Graphite
• fullerene C60

Topics

• Antineoplastic Agents (chemistry, pharmacology)
• Calixarenes (chemistry)
• Cell Line, Tumor
• Fullerenes (chemistry)
• Graphite (chemistry)
• Humans
• Lasers
• Molecular Conformation
• Nanotubes, Carbon (chemistry)
• Neuroblastoma (drug therapy)
• Phosphorous Acids (chemistry)
• Photochemotherapy
• Reactive Oxygen Species (metabolism)
• Solubility
• Surface Properties
• Water