Finalization of autologous stem cell transplant in complex and multirelapsed follicular lymphoma.

Abstract

BACKGROUND:

Follicular lymphoma (FL) is characterized by frequent relapses and need for multitude lines of therapy, which includes different immunochemotherapy regimens, novel monoclonal antibodies, novel drugs, and autologous or allogenic stem cell transplant. Early use of autologous stem cell transplantation (ASCT) improves prognosis in patients with FL who may be candidates for an aggressive approach.

CASE PRESENTATION:

We report the case of a 49-year-old woman with thrombophilia with relapsed/refractory grade 3A FL, heavily pretreated, who achieved third complete remission after high-dose chemotherapy and ASCT, despite experiencing life-threatening adverse events during her treatment history.

CONCLUSIONS:

Stem cell transplantation has emerged as the standard of care for young patients with FL but may be effective also in complex and multirelapsed clinical cases.

• Authors: Matteo Carella, Vittorio Stefoni, Cinzia Pellegrini, Lisa Argnani, Michele Cavo, Pier Luigi Zinzani
• Journal: Tumori (Tumori) Vol. 106 Issue 6 Pg. NP5-NP8 (Dec 2020) ISSN: 2038-2529 [Electronic] United States
• PMID: 32442038 (Publication Type: Case Reports, Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Combined Modality Therapy
• Female
• Hematopoietic Stem Cell Transplantation (adverse effects, methods)
• Humans
• Lymphoma, Follicular (pathology, therapy)
• Magnetic Resonance Imaging
• Middle Aged
• Neoplasm Staging
• Recurrence
• Retreatment
• Transplantation, Autologous
• Treatment Outcome