Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Alpinia Oxyphylla Miquel is a widely used traditional herbal medicine for the treatment of abdominal pain, intestinal disorders, enuresis, and inflammatory conditions. AIM OF THE STUDY: In this study we aimed to demonstrate the anti-inflammatory and anti-nociceptive effects of Alpinia Oxyphylla Miquel extracts with 50% ethanol (AOE) in animal models. MATERIAL AND METHOD: RESULTS: Compared with the control, AOE caused a significant inhibition of paw edema, ear thickness, and abdominal constriction in animals. Compared with untreated explants exposed to interleukin-l alpha (IL-1α), preoteoglycan degradation by IL-1α was inhibited (18.2%-82.0%) in explants treated with AOE (50-400 μg/ml). In vitro, IC50 values of AOE were 299.87, 199.07, and 170.29 μg/ml for COX-1, COX-2, and 5-LOX respectively. CONCLUSIONS: These data demonstrate the potent anti-inflammatory and analgesic effects of AOE and suggest AOE to be useful for the treatment of osteoarthritis and/or associated symptoms.
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Authors | Su Hyun Yu, Hyun Jin Kim, Se Yeong Jeon, Mi Ran Kim, Bo Su Lee, Jeong Jun Lee, Dong-Seon Kim, Young Chul Lee |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 260
Pg. 112985
(Oct 05 2020)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 32439403
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier B.V. All rights reserved. |
Chemical References |
- Analgesics
- Anti-Inflammatory Agents
- Plant Extracts
- Carrageenan
|
Topics |
- Alpinia
(chemistry)
- Analgesics
(isolation & purification, pharmacology)
- Animals
- Anti-Inflammatory Agents
(isolation & purification, pharmacology)
- Carrageenan
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Edema
(drug therapy)
- Inflammation
(drug therapy)
- Inhibitory Concentration 50
- Mice
- Mice, Inbred ICR
- Pain
(drug therapy)
- Plant Extracts
(pharmacology)
- Rats
- Rats, Sprague-Dawley
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