Abstract |
The therapeutic effects of the olibanum, the resin of Boswellia serrata on inflammatory diseases have been reported. There are more than 200 active ingredients in this resin including acetyl-11-keto-β-boswellic acid (AKBA). We proposed that AKBA can improve memory impairment induced by cerebral inflammation following the administration of lipopolysaccharide (LPS). Forty male rats were grouped and received the following treatments: Control (diluted DMSO + saline), LPS (diluted DMSO + 1 mg/kg LPS), LPS- AKBA 5 and LPS- AKBA 10 (5 or 10 mg/ kg AKBA before LPS). Morris water maze (MWM), passive avoidance (PA) and biochemical tests were carried out. Pre-treatment with both doses of AKBA improved memory performance in MWM and PA tests (P < 0.05 to P < 0.001). Pre-treatment by AKBA improved the levels of hippocampal IL-10 (P < 0.001), BDNF (P < 0.001), CAT (P < 0.05 and P < 0.001), SOD P < 0.001 and thiols (P < 0.01 and P < 0.001) while reduced IL-6 (P < 0.001), TNF-α (P < 0.001), NO (P < 0.05 and P < 0.001), GFAP (P < 0.001) and MDA (P < 0.001) levels. AKBA effectively ameliorated LPS-induced learning and memory impairments and improved BDNF in a neuroinflammation animal model. The effects seem to be due to setting a positive balance between pro-inflammatory to inflammatory cytokines and reinvigorate the antioxidant system.
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Authors | Narges Marefati, Farimah Beheshti, Sara Memarpour, Reza Bayat, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Hamed Ghazavi, Mahmoud Hosseini |
Journal | Cytokine
(Cytokine)
Vol. 131
Pg. 155107
(07 2020)
ISSN: 1096-0023 [Electronic] England |
PMID | 32380425
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
Chemical References |
- Bdnf protein, rat
- Brain-Derived Neurotrophic Factor
- Cytokines
- GFAP protein, rat
- Glial Fibrillary Acidic Protein
- Inflammation Mediators
- Lipopolysaccharides
- Triterpenes
- acetyl-11-ketoboswellic acid
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Topics |
- Animals
- Avoidance Learning
(drug effects)
- Brain-Derived Neurotrophic Factor
(metabolism)
- Cytokines
(metabolism)
- Glial Fibrillary Acidic Protein
(metabolism)
- Hippocampus
(drug effects, metabolism)
- Inflammation Mediators
(metabolism)
- Lipopolysaccharides
(toxicity)
- Male
- Memory
(drug effects)
- Morris Water Maze Test
- Oxidative Stress
(drug effects)
- Rats, Wistar
- Triterpenes
(pharmacology)
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