Recognizing Inadequate Response in Patients With Major Depressive Disorder.

Abstract

​​ ​​ Being able to recognize inadequate response to antidepressant treatment and distinguish it from treatment-resistant depression is key in order for clinicians to provide appropriate therapies. Although definitions vary, nonresponse is often defined as less than 25% improvement on a standardized rating scale, and partial response, as more than 25% but less than 50% improvement. Residual symptoms characteristic of inadequate response (less than 50% improvement) include low mood, anxiety, irritability, guilt, and somatic symptoms. Various factors that may contribute to inadequate response to an antidepressant include inadequate dose or duration, poor adherence, and misdiagnosis. ​.

• Authors: W Clay Jackson, George I Papakostas, Roueen Rafeyan, Madhukar H Trivedi
• Journal: The Journal of clinical psychiatry (J Clin Psychiatry) Vol. 81 Issue 3 (05 05 2020) ISSN: 1555-2101 [Electronic] United States
• PMID: 32369684 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © Copyright 2020 Physicians Postgraduate Press, Inc.

Chemical References

• Antidepressive Agents

Topics

• Antidepressive Agents (therapeutic use)
• Depressive Disorder, Major (diagnosis, drug therapy, psychology)
• Humans
• Psychiatric Status Rating Scales
• Treatment Failure