Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids.

Abstract

Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We present 2 cases of DILI that improved with corticosteroid therapy despite the lack of autoimmune features by serology or histology. The current observations make a strong case for formally testing corticosteroids in a controlled trial in patients with suspected DILI.

• Authors: Suneha Sundaram, Raj Vuppalanchi, Romil Saxena, Naga Chalasani
• Journal: ACG case reports journal (ACG Case Rep J) Vol. 7 Issue 2 Pg. e00319 (Feb 2020) ISSN: 2326-3253 [Print] United States
• PMID: 32309510 (Publication Type: Case Reports)
• Copyright: © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.