Abstract | BACKGROUND: PATIENTS AND METHODS: A total of 171 patients with DEACMP were recruited and assigned to the combined therapy group (receiving NBP and DXM 5 mg/day plus HBO therapy) or the control group (HBO therapy as monotherapy). Conventional treatments were provided for all patients. The cognition and movement changes in patients were evaluated by the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA) scale and the Barthel index of activities of daily living ( ADL) before and after the treatment at 1 month, 3 months, and 1 year, respectively. RESULTS: At 1 month, 3 months, and 1 year after the treatment, the MMSE, MoCA and ADL scores were all significantly higher in the combined therapy group than those in the control group. There were no significant alterations in blood glucose, blood lipids, or liver and kidney function during the whole treatment session. Some patients experienced loss of appetite, mild headache and minor skin irritations. However, these patients recovered by themselves and needed no additional medications or special treatment. CONCLUSION: These results indicated that NBP and DXM combined with HBO for the treatment of DEACMP can significantly improve the cognitive and motor functions of patients and is very safe.
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Authors | Jiefang Zhang, Yuewen Guo, Wenyao Li, Guangli Li, Yankun Chen |
Journal | Drug design, development and therapy
(Drug Des Devel Ther)
Vol. 14
Pg. 1333-1339
( 2020)
ISSN: 1177-8881 [Electronic] New Zealand |
PMID | 32308366
(Publication Type: Journal Article)
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Copyright | © 2020 Zhang et al. |
Chemical References |
- Benzofurans
- Dexamethasone
- 3-n-butylphthalide
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Topics |
- Activities of Daily Living
- Acute Disease
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Benzofurans
(administration & dosage, therapeutic use)
- Brain Diseases
(etiology, pathology, prevention & control)
- Carbon Monoxide Poisoning
(complications, pathology, therapy)
- Combined Modality Therapy
- Dexamethasone
(administration & dosage, therapeutic use)
- Female
- Humans
- Hyperbaric Oxygenation
- Male
- Middle Aged
- Young Adult
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