Serum IGFBP2 Level Is a New Candidate Biomarker of Severe Malnutrition in Advanced Lung Cancer.

Abstract

Objectives: This study aimed to analyze and evaluate serum insulin-like growth factor-binding protein 2 (IGFBP2) levels as a new biomarker of severe malnutrition in patients with advanced lung cancer.Design and methods: This prospective study involved 59 patients with advanced lung cancer. We detected serum IGFBP2 level by using enzyme-linked immunosorbent assay and analyzed its relationship to clinical characteristics, nutritional status, Glasgow prognostic score (GPS), and survival. Serum albumin and C-reactive protein (CRP) levels were measured, and nutritional status was assessed using Patient-Generated Subjective Global Assessment (PG-SGA). The best cutoff point value for serum IGFBP2 level was established using receiver operating characteristic analysis. Kaplan-Meier method was utilized to analyze the survival curves.Results: Serum IGFBP2 levels were elevated in patients with advanced lung cancer and severe malnutrition. The best cutoff value for serum IGFBP2 level was determined at 363 ng/ml, which could diagnose severe malnutrition with 73.3% sensitivity and 70.5% specificity and was found to be related to albumin, CRP, and GPS. Patients whose serum IGFBP2 levels were higher than 363 ng/ml had poor survival outcome.Conclusion: This study demonstrates the remarkably association between higher serum level of IGFBP2 and severe malnutrition, albumin, CRP, GPS, and survival. Hence, serum IGFBP2 level can be used as a potential biomarker for diagnosis of severe malnutrition in patients with advanced lung cancer.

• Authors: Jie Dong, Yaqi Zeng, Ping Zhang, Chunlei Li, Yajun Chen, Yueying Li, Kun Wang
• Journal: Nutrition and cancer (Nutr Cancer) Vol. 72 Issue 5 Pg. 858-863 ( 2020) ISSN: 1532-7914 [Electronic] United States
• PMID: 32286106 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• IGFBP2 protein, human
• Insulin-Like Growth Factor Binding Protein 2

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (blood)
• Carcinoma, Non-Small-Cell Lung (complications, pathology)
• Case-Control Studies
• Female
• Humans
• Insulin-Like Growth Factor Binding Protein 2 (blood)
• Lung Neoplasms (blood, pathology)
• Male
• Malnutrition (blood, diagnosis, etiology, pathology)
• Middle Aged
• Prognosis
• Prospective Studies
• ROC Curve