Neurofibromatosis Type 1 with the Development of Pheochromocytoma and Breast Cancer.

Abstract

A 40-year-old woman presented with a left adrenal incidentaloma. Based on the presence of café-au-lait spots, cutaneous neurofibroma, and family history, she was diagnosed with neurofibromatosis type 1 (NF1). Adrenal incidentaloma screening showed an elevated normetanephrine level; the left adrenal mass showed the uptake of I-123 meta-iodobenzylguanidine. She underwent left adrenalectomy, and pheochromocytoma was diagnosed. One year later, the results of a biopsy of a palpable mass in the left breast suggested invasive ductal carcinoma. The patient underwent neoadjuvant chemotherapy followed by left breast-conserving surgery. We herein report a rare case of an NF1 patient who developed both pheochromocytoma and breast cancer.

• Authors: Yu Hee Lee, Min Jeong Kwon, Jeong Hyun Park, Su Jin Jeong, Tae Hyun Kim, Hae Woong Jeong, Soon Hee Lee
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 59 Issue 13 Pg. 1665-1669 (Jul 01 2020) ISSN: 1349-7235 [Electronic] Japan
• PMID: 32269189 (Publication Type: Case Reports, Journal Article)

Topics

• Adrenal Gland Neoplasms (complications, surgery)
• Adrenalectomy
• Adult
• Biopsy
• Breast Neoplasms (complications, therapy)
• Cafe-au-Lait Spots (pathology)
• Female
• Humans
• Incidental Findings
• Neurofibromatosis 1 (complications)
• Pheochromocytoma (complications)
• Skin Neoplasms (pathology)