Case of using mycophenolate in combination with steroids for concurrent macrophage activation syndrome and lupus flare.

Abstract

This report highlights the importance of tailored treatment strategies in severe systemic lupus erythematosus (SLE) flares driving the life-threatening condition, macrophage activation syndrome (MAS). We report the case of a 42-year-old woman with active systemic lupus erythematosus (SLE) who was diagnosed with MAS within 3 days of onset of lethargy, rash, joint pain and significant cytopenias. This early diagnosis meant that her condition was managed with less intensive immunosuppression with only modest doses of steroids and mycophenolate mofetil.

• Authors: Kavina Shah, Andrew Porter, Gagandeep Takhar, Venkat Reddy
• Journal: BMJ case reports (BMJ Case Rep) Vol. 13 Issue 4 (Apr 07 2020) ISSN: 1757-790X [Electronic] England
• PMID: 32269047 (Publication Type: Case Reports, Journal Article)
• Copyright: © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Chemical References

• Enzyme Inhibitors
• Glucocorticoids
• Prednisolone
• Mycophenolic Acid

Topics

• Adult
• Diagnosis, Differential
• Drug Therapy, Combination
• Enzyme Inhibitors (therapeutic use)
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Lupus Erythematosus, Systemic (complications, drug therapy)
• Macrophage Activation Syndrome (drug therapy, etiology)
• Mycophenolic Acid (therapeutic use)
• Prednisolone (therapeutic use)