Abstract |
HLA-A, -B, -C, -DR, and -DQ antigen phenotypes were determined in 266 Caucasian homosexual men, 90 of whom were HIV-1 seronegative, 94 HIV-1 seropositive AIDS-free, and 82 with a diagnosis of AIDS [36 with Kaposi's sarcoma (KS), 34 with opportunistic infection (OI), and 12 with KS and OI]. No significant differences in HLA-A or -B antigen frequencies were found in any comparisons of these groups. However, in comparisons of seropositive AIDS-free men with the AIDS groups, HLA-Cw7 was increased in frequency in OI and HLA-DR1, -DRw14, and -DQw1 in KS. HLA-DR3 and -DQw3 frequencies were decreased in KS, and DRw53 was decreased in OI. In a cohort of 102 HIV seropositive individuals that were followed for a mean of 43 months, AIDS developed in HLA-DR1 positive men more frequently than in individuals with other HLA-DR phenotypes (p = 0.02). These results demonstrate probable genetic differences between individuals developing KS and OI and indicate that the HLA-DR1 phenotype is a risk factor in disease progression in human immunodeficiency virus (HIV)-infected individuals.
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Authors | D L Mann, C Murray, R Yarchoan, W A Blattner, J J Goedert |
Journal | Journal of acquired immune deficiency syndromes
(J Acquir Immune Defic Syndr (1988))
Vol. 1
Issue 1
Pg. 13-7
( 1988)
ISSN: 0894-9255 [Print] United States |
PMID | 3216293
(Publication Type: Journal Article)
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Chemical References |
- HLA Antigens
- HLA-A Antigens
- HLA-B Antigens
- HLA-C Antigens
- HLA-DQ Antigens
- HLA-DR Antigens
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Topics |
- Acquired Immunodeficiency Syndrome
(complications, immunology)
- HIV Seropositivity
(immunology)
- HIV-1
- HLA Antigens
(analysis)
- HLA-A Antigens
(analysis)
- HLA-B Antigens
(analysis)
- HLA-C Antigens
(analysis)
- HLA-DQ Antigens
(analysis)
- HLA-DR Antigens
(analysis)
- Humans
- Male
- Opportunistic Infections
(complications, immunology)
- Sarcoma, Kaposi
(etiology, immunology)
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