Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.

Abstract

AIMS:

A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan, China (COVID-19). Until today >2700 deaths from the 80,000 confirmed cases reported mainly in China and 40 other countries. Human to human transmission is confirmed for COVID-19 by China a month ago. Based on the World Health Organization (WHO) reports, SARS HCoV is responsible for >8000 cases with confirmed 774 deaths. Additionally, MERS HCoV is responsible for 858 deaths out of about 2500 reported cases. The current study aims to test anti-HCV drugs against COVID-19 RNA dependent RNA polymerase (RdRp).

MATERIALS AND METHODS:

In this study, sequence analysis, modeling, and docking are used to build a model for Wuhan COVID-19 RdRp. Additionally, the newly emerged Wuhan HCoV RdRp model is targeted by anti-polymerase drugs, including the approved drugs Sofosbuvir and Ribavirin.

KEY FINDINGS:

The results suggest the effectiveness of Sofosbuvir, IDX-184, Ribavirin, and Remidisvir as potent drugs against the newly emerged HCoV disease.

SIGNIFICANCE:

The present study presents a perfect model for COVID-19 RdRp enabling its testing in silico against anti-polymerase drugs. Besides, the study presents some drugs that previously proved its efficiency against the newly emerged viral infection.

• Authors: Abdo A Elfiky
• Journal: Life sciences (Life Sci) Vol. 248 Pg. 117477 (May 01 2020) ISSN: 1879-0631 [Electronic] Netherlands
• PMID: 32119961 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Antiviral Agents
• IDX184
• Viral Proteins
• remdesivir
• Adenosine Monophosphate
• Ribavirin
• Guanosine Monophosphate
• Guanosine Triphosphate
• RNA-Dependent RNA Polymerase
• Alanine
• Uridine Triphosphate
• Sofosbuvir

Topics

• Adenosine Monophosphate (analogs & derivatives, chemistry, metabolism)
• Alanine (analogs & derivatives, chemistry, metabolism)
• Alphacoronavirus (enzymology, genetics)
• Amino Acid Sequence
• Antiviral Agents (chemistry, metabolism)
• Betacoronavirus (enzymology, genetics)
• COVID-19
• Catalytic Domain
• Computational Biology (methods)
• Coronavirus Infections (drug therapy, virology)
• Drug Repositioning (methods)
• Guanosine Monophosphate (analogs & derivatives, chemistry, metabolism)
• Guanosine Triphosphate (chemistry, metabolism)
• Humans
• Molecular Docking Simulation
• Pneumonia, Viral (drug therapy, virology)
• Protein Binding
• Protein Conformation, alpha-Helical
• Protein Conformation, beta-Strand
• Protein Interaction Domains and Motifs
• RNA-Dependent RNA Polymerase (antagonists & inhibitors, chemistry, metabolism)
• Ribavirin (chemistry, metabolism)
• SARS-CoV-2
• Sequence Alignment
• Sequence Homology, Amino Acid
• Sofosbuvir (chemistry, metabolism)
• Thermodynamics
• Uridine Triphosphate (chemistry, metabolism)
• Viral Proteins (antagonists & inhibitors, chemistry, metabolism)
• COVID-19 Drug Treatment