Gonococcal urethritis caused by a multidrug resistant Neisseria gonorrhoeae strain with high-level resistance to spectinomycin in China.

Abstract

We report a recent (2018) gonorrhoeal urethritis caused by a multidrug-resistant Neisseria gonorrhoeae strain in China. The isolated N. gonorrhoeae strain from a male and female pair expressed high-level resistance to spectinomycin (SPC), azithromycin, and other antibiotics but was sensitive to ceftriaxone. The SPC high-level resistance (MIC = 2048 mg/L) was due to a small deletion in rspE that caused two amino acid changes in ribosomal protein S5.

• Authors: Shao-Chun Chen, Li-Hua Hu, Xiao-Yu Zhu, Yue-Ping Yin
• Journal: Emerging microbes & infections (Emerg Microbes Infect) Vol. 9 Issue 1 Pg. 517-519 ( 2020) ISSN: 2222-1751 [Electronic] United States
• PMID: 32116136 (Publication Type: Letter)

Chemical References

• Ribosomal Proteins
• Spectinomycin

Topics

• China
• Drug Resistance, Multiple, Bacterial
• Neisseria gonorrhoeae (drug effects, genetics, metabolism)
• Phenotype
• Ribosomal Proteins (genetics, metabolism)
• Spectinomycin (pharmacology)