Abstract |
Inflammasomes are intracellular multiprotein complexes in the cytoplasm that regulate inflammation activation in the innate immune system in response to pathogens and to host self-derived molecules. Recent advances greatly improved our understanding of the activation of nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasomes at the molecular level. The NLRP3 belongs to the subfamily of NLRP which activates caspase 1, thus causing the production of proinflammatory cytokines ( interleukin 1β and interleukin 18) and pyroptosis. This inflammasome is involved in multiple neurodegenerative and metabolic disorders including Alzheimer's disease, multiple sclerosis, type 2 diabetes mellitus, and gout. Therefore, therapeutic targeting to the NLRP3 inflammasome complex is a promising way to treat these diseases. Recent research advances paved the way toward drug research and development using a variety of machine learning-based and artificial intelligence-based approaches. These state-of-the-art approaches will lead to the discovery of better drugs after the training of such a system.
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Authors | Rameez Hassan Pirzada, Nasir Javaid, Sangdun Choi |
Journal | Genes
(Genes (Basel))
Vol. 11
Issue 2
(01 27 2020)
ISSN: 2073-4425 [Electronic] Switzerland |
PMID | 32012695
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- NLR Family, Pyrin Domain-Containing 3 Protein
- NLRP3 protein, human
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Topics |
- Alzheimer Disease
(metabolism)
- Diabetes Mellitus, Type 2
(metabolism)
- Humans
- Metabolic Diseases
(metabolism, therapy)
- NLR Family, Pyrin Domain-Containing 3 Protein
(metabolism, physiology)
- Neurodegenerative Diseases
(metabolism, therapy)
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