Effects of Kuntai capsule on breast pain and vaginal bleeding in postmenopausal women.

Abstract

Aim of the present work was to investigate the clinical efficacy of Kuntai capsule in the treatment of postmenopausal women with endometriosis, Breast pain and Vaginal Bleeding. 120 elderly female outpatients over 50 years old with Breast pain were randomly divided into control group (60 cases) and observation group (60 cases). All patients were given diclofenac sodium enteric-coated tablets 25mg, 3 times a day. The observation group was given additional Kuntai capsules at a dose of 4 capsules per time, 3 times a day. Serum estradiol (E2), follicle stimulating hormone (FSH), and luteinizing hormone (LH) were detected in all patients before and at 12 weeks after treatment. Modified Kupperman score (K score) for evaluating menopausal symptoms. The post therapeutic serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) level and endometrial thickness decreased significantly (p<0.05). After treatment, KMI scores of kunati group was significantly decreased compared with baseline (<0.01) and there was no significant difference between groups (p>0.05). After treatment, hot flush and insomnia scores were both improved significantly. After therapy, serum E2 level obviously higher than the control groups, while FSH and LH levels were obviously lower (p<0.05). The incidence of vaginal bleeding, breast distending pain in group was obviously higher in control group than Kuntai group. Thus, Kuntai capsule improved the ovarian function of patients, raised the level of estrogen in vivo and alleviates the clinical manifestations of Breast pain.

• Authors: Xiaoxia Qi, Yun Guo, Lingna Sun
• Journal: Pakistan journal of pharmaceutical sciences (Pak J Pharm Sci) Vol. 32 Issue 5(Special) Pg. 2471-2476 (Sep 2019) ISSN: 1011-601X [Print] Pakistan
• PMID: 31894037 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Drugs, Chinese Herbal
• Estrogens
• kuntai capsule
• Follicle Stimulating Hormone

Topics

• Drugs, Chinese Herbal (therapeutic use)
• Estrogens (blood, metabolism)
• Female
• Follicle Stimulating Hormone (blood)
• Humans
• Mastodynia (drug therapy)
• Middle Aged
• Postmenopause
• Uterine Hemorrhage (drug therapy)